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The coexistence of hypotestosteronemia and elevated dihydrotestosterone (DHT) levels negatively impacts hair follicles. While testosterone supports pilary growth, DHT, a more potent androgen, induces follicular miniaturization in genetically susceptible individuals, contributing to alopecia. Hormonal dysregulation is a key etiological factor.
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Low testosterone and high dihydrotestosterone (DHT) create a suboptimal environment for hair follicles, potentially leading to hair issues.
Testosterone supports hair growth but converts to the more potent DHT. In genetically predisposed individuals, DHT binding causes follicular miniaturization and hair loss.
Concurrent low testosterone and high DHT exacerbate follicular miniaturization and accelerate hair thinning and loss in susceptible individuals.
Low testosterone in men generally has more pronounced and systemic negative health consequences compared to high testosterone.
Chronically low testosterone is associated with decreased libido, erectile dysfunction, reduced muscle mass and strength, decreased bone density, fatigue, cognitive impairment, and mood disturbances. Its also linked to increased risks of cardiovascular problems and metabolic syndrome.
Elevated testosterone may cause acne, oily skin, increased body hair, and potentially mood swings. Exogenously induced high levels can carry long-term risks like prostate enlargement and cardiovascular issues, unlike typically milder effects of naturally higher levels.